Complement as a Therapeutic Target in Systemic Autoimmune Diseases

The complement system (CS) includes more than 50 proteins and its main function is to recognize protect against foreign or damaged molecular components. Other homeostatic functions of CS are the elimination apoptotic debris, neurological development, control adaptive immune responses. Pathological activation plays prominent roles in pathogenesis most autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, rheumatoid arthritis, dermatomyositis, ANCA-associated vasculitis. In this review, we will review rheumatologic processes which a pathogenic role potential relevance therapeutic target.